Romeos centers on Lukas (Rick Okon), a trans-man in his early 20s who has just moved to Cologne on his work-study. Outwardly, Lukas passes as cis-gender (which is what he wants) but he is still in the process of transitioning. His best friend from home, Ine (Liv Lisa Fries), is in the same work-study as him, she is his only confidante. He becomes friends with Sven (Felix Brocke) and strikes up an unlikely romance with the promiscuous bisexual, Fabio (Max Befort).